Dana-Farber / Brigham and Women's Cancer Center

Dana-Farber, Brigham and Women’s launch Profile, one of the most comprehensive research initiatives in personalized cancer medicine

Dana-Farber, Brigham and Women’s launch Profile, one of the most comprehensive research initiatives in personalized cancer medicine

Genotyping for the Profile cancer research study is performed in the Brigham and Women’s Hospital Center for Advanced Molecular Diagnostics, a CLIA-certified laboratory.

Committed to speeding the development of cancer treatments that target the genetic weaknesses in each patient’s tumor, Dana-Farber Cancer Institute and Brigham and Women’s Hospital launched Profile®, a major effort to scan tumor tissue from adult cancer patients for hundreds of gene mutations linked to cancer.

The program, nearly two years in development, is one of the most extensive research projects in cancer genomics yet undertaken nationally. Open to every adult cancer patient seen in the Brigham and Women’s and Dana-Farber Longwood Medical Area clinics, the program aims to build a comprehensive database for research into the genetic makeup of different cancer types and, ultimately, into treatments that are most effective against individual tumors.

Clinicians at Dana-Farber/Brigham and Women’s Cancer Center currently use targeted therapies that pinpoint genetic mutations in a select number of cancers, including colon, lung, breast, and some leukemias and sarcomas. The new research program is focused on identifying a far greater number of mutations for a wider array of cancers, ultimately enabling clinicians to treat more cancers with targeted therapies in the future.

"Profile will put us firmly on the path to realizing the promise of personalized medicine. By ‘genotyping’ each tumor – identifying the set of mutations that drive it – we'll be able to design therapies geared specifically to those mutations, depriving the tumor of the ability to sustain itself while producing a minimum of side effects," says Dana-Farber’s Chief Scientific Officer Barrett Rollins, MD, PhD, one of the architects of the program. "We’re laying the foundation for the development, testing, and implementation of such therapies, and we expect the project to grow as we discover new cancer-related gene mutations and with the development of new technologies."

Tissue-testing for the program is performed with OncoMap, a system custom-designed for genomic research in cancer by investigators at Dana-Farber and the Broad Institute of MIT and Harvard. Using high-speed, high-capacity robotic machinery to prepare, sort, and scan tumor tissue, the system makes it possible to quickly process large numbers of tumor tissue samples with a high degree of accuracy.

Research has shown that tumors that look and act alike can carry different sets of mutations, which influence how cancers grow, spread, and respond to treatment. Only by collecting data on a mass scale can researchers hope to capture the enormous diversity of cancer at the genetic level, program leaders say. By identifying a tumor’s molecular characteristics, clinicians will be able to select the appropriate treatment for each patient. A patient whose tumor carries a particular mutation would receive a drug known to be effective against that mutation in specific types of tissue. Although this currently happens in a minority of cancer cases, the goal of the Dana-Farber/Brigham and Women’s project is to find ways to apply this to many more patients.

In contrast to programs that scan particular types of tumors for a small number of gene mutations, Profile tests tumor samples for 471 somantic mutations in 41 genes. Program leaders anticipate that well over 10,000 people will participate in the program during the first year and every year thereafter.

Study participants have their tumor tissue scanned and information from their medical record – on the course of their disease, its response to treatment, relapse, and side effects – will be placed in a second, separate database. By linking data from these two sources, researchers will be able to study which therapies are most effective against particular tumor types.

The study participants also can have the results of their OncoMap testing sent to their Dana-Farber or Brigham physician. The tumor-testing program was developed primarily for research purposes, but leaders expect that some participants may immediately benefit by learning of their eligibility for current clinical trials.

Researchers anticipate that Profile will expand with the discovery of additional cancer-related mutations and the development of more advanced screening technologies.

Key leaders of the new genetic-screening research program include Monica Bertagnolli, MD, Chief of the Division of Surgical Oncology at Brigham and Women’s Hospital, and Philip Kantoff, MD, Chief Clinical Research Officer at Dana-Farber Cancer Institute.

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Large-scale genomic database project at Dana-Farber Cancer Institute and Brigham Women's Hospital

Benz, Jr., MD comments on the Annual Report to the Nation

Barrett Rollins, MD, PhD, Chief Scientific Officer at Dana-Farber Cancer Institute, speaks about Profile®, one of the most comprehensive cancer research studies to help accelerate the development of personalized treatments for every person with cancer.

 

Harvard Medical School© 2012 Dana-Farber/Brigham and Women's Cancer Center, Boston, MA
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